I'm no pro on this but do maintain 3 of these engines that are in C-60 GMC frames. I think you're going to have both length and width problems. Never measured the width of the frames but I would bet the p/u frame is going to be narrower than the medium duty ones. Another potential problem is going to be clearance to the hood. The meduim duty trucks hae either the high rise hoods or a tilt front. I'd take some good measurements before doing anything else. Not saying it can't be done but may lead into a major modification of the truck itself. As for the 366 engine, not too many problems with these that I have seen. The ones I deal with are used on oil trucks and get high hours and milage. I just replaced one a few weeks back that spun a bearing a chewed the block up when the crank snapped however, it had around 275K miles on it at the time (no idea on hours but very high from running the PTO pump). The other two have around or over 200K on them. I'd strongly suggest replacing the oil pump, rear main seal and head gaskets before you install it. These seem to be the common failures and are a lot easier to do when it's hanging on a stand out in the open. Also while it's out, you may wish to replace all the exhaust bolts with new ones too. If you got luck like me, it sure to snap a manifold two days after you get it in the truck. Sorry I can't be of any real help on this.
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