According to Google maps, and assuming you are going through Sioux City SD (used it as the starting point) it is 50 miles shorter if you only drop down to Omaha and catch I-80 east.
I just use it to find distances. I use a map and esperience for routing.
Take I-74 from the quad cities to Indianapolis, I-70 to Dayton, Ohio, I-75 south through the city to route 35, which is all 4-lane to Charleston save a few miles in West Virginia.
From there you'll follow 77 south to North Carolina, where you'll make a left exit onto I-74 a couple miles past the scale house.
At Winston-Salem, you'll want to take route 421 east, but if you miss it you can go a few more miles and catch I-40 directly. Which is often easier, depending on what time you hit.
That way you hit Des Moines, Indy, and Dayton, but you avoid Kansas City, St Louis, Louisville, Nashville, Knoxville, and Statesville. The canyon is pretty crooked at the east end of Tennessee as well. I77 can be crooked too, but they have a little more equipment for getting snow off the road.
Actually, if I wanted to get down and get on I-40 as soon as possible I'd take 64 out of St Louis, then 57 south to I-24, which will hook you up with 40 in Crashville.
Used to see a lot of North Carolina, ran down there/through there out of Erie, PA. Had a dispatcher for a few months that couldn't dispatch. What you did the week that the old dispatcher left, is what you did all summer. They finally canned him the day I strongly hinted at bodily harm if I made the same two trips for a third week in a row, in front of the boss' wife.
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