Purported uses Prevention of drug-induced hepatotoxicity Bronchitis Cancer prevention Chronic obstructive pulmonary disorders Cirrhosis Cystic fibrosis HIV and AIDS Lou Gehrigs Disease
Mechanism of Action NAC is a precursor to intracellular glutathione. It is a known nucleophile and free radical scavenger, either directly or as a source of cysteine and glutathione. In rodent models, NAC inhibits a variety of mutagen/carcinogen-induced cancer biomarkers, interferes with the promotion phase of multistage carcinogenesis, and produces a decrease in the incidence of carcinogen-induced tumors of the lung, colon, and bladder. This activity may be due to its ability to enhance glutathione S-transferases, glutathione peroxidase, glutathione reductase, and NADH- and NADPH-quinone reductase. In vitro and in animal models, NAC exhibits anti-invasive, antimetastatic, and antiangiogenic properties. In one study, NAC was found to inhibit the proliferation of androgen-independent human PC-3 prostate cancer cells through upregulation of Cyr61 protein expression. NAC can also be employed as a mucolytic agent in the treatment of respiratory diseases and as an antidote to acetaminophen poisoning. Animal studies report that NAC may also protect against doxorubicin toxicity and bladder cystitis induced by ifosfamide and cyclophosphamide.
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Today's Featured Article - Women and Tractors - Tractor Engine Repair - by Teri Burkholder. One of the great things about working on a tractor engine with your other half is that you know what he is thinking of at all times and can anticipate his every move and his next thought of what he will do. With Ben, anyway, I can tell! He'll be busy working and I�m handing him tools and he says, "give me that..." and I�ve already got it in his hand or "hand me that....."and I�ve got the portable light right where he needed it placed to see. "Run in the house and get me a...."as I open th
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