Purported uses Prevention of drug-induced hepatotoxicity Bronchitis Cancer prevention Chronic obstructive pulmonary disorders Cirrhosis Cystic fibrosis HIV and AIDS Lou Gehrigs Disease
Mechanism of Action NAC is a precursor to intracellular glutathione. It is a known nucleophile and free radical scavenger, either directly or as a source of cysteine and glutathione. In rodent models, NAC inhibits a variety of mutagen/carcinogen-induced cancer biomarkers, interferes with the promotion phase of multistage carcinogenesis, and produces a decrease in the incidence of carcinogen-induced tumors of the lung, colon, and bladder. This activity may be due to its ability to enhance glutathione S-transferases, glutathione peroxidase, glutathione reductase, and NADH- and NADPH-quinone reductase. In vitro and in animal models, NAC exhibits anti-invasive, antimetastatic, and antiangiogenic properties. In one study, NAC was found to inhibit the proliferation of androgen-independent human PC-3 prostate cancer cells through upregulation of Cyr61 protein expression. NAC can also be employed as a mucolytic agent in the treatment of respiratory diseases and as an antidote to acetaminophen poisoning. Animal studies report that NAC may also protect against doxorubicin toxicity and bladder cystitis induced by ifosfamide and cyclophosphamide.
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Today's Featured Article - Tractor Proflie: Farmall Model C - by Staff. In 1948 the first Farmall Model C tractor rolled out of the factory and into the farmer's field. A follow-on to the Model B, it was slihtly larger in size but kept the same 113 CID engine and 4-speed transmission. Other upgrades included adjustable rear tire spacing (with sliding hubs), a frame design similar t
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