Tool boxes need to be organized just like anything else. If you just dump stuff into whatever drawer is open, of COURSE you'll never find what you're looking for.
Screw drivers - one drawer with slots. Phillips on one side, straight on the other
Pliers - one drawer
SAE Wrenches - one drawer with racks, wrenches arranged by size.
Metric Wrenches - See SAE wrenches
Sockets - one drawer for 3/8 and 1/2 drive with sockets slots arranged by size, separated by drive size, regular and deep and SAE and Metric
Second drawer for 1/4 drive arranged the same way
There's more, but you get the idea.
Also, put ALL the tools away after EVERY job. I can tell with a glance in a drawer if I've missed something.