I've used Bullseye for reduced power .38 spcl target loads. It's pretty good behind 148 gr lead full wadcutter bullets, although it's not my powder of choice.
I have lots of 2400 which I use for magnum handgun loads. In case you don't already know this, here's something not to try with 2400. Don't use it for reduced power loads. The only time I ever had a bullet not get all the way out of the barrel was experimenting with reduced power .38 spcl (or possibly .357 mag---although now it's hard to see what the point of that would have been) loads. I was target shooting with a .357 mag with a 4" barrel. I was wearing so much hearing protection that I didn't fully hear the difference in the sound of the discharge. Fortunately, something felt not quite right, and I must have had some inkling about what could happen, so I didn't fire another round until I investigated. A second round might or might not have blown up the revolver. A S&W certified gunsmith once told me that he had worked on a S&W revolver that had three bullets lodged in the barrel, and hadn't blown up. The final bullet was stuck in the end of the cylinder and the forcing cone of the barrel. That locked up the revolver and kept the careless owner from squeezing off a couple more. The gunsmith had to use a jewelers saw to cut the bullet in half before he could get the cylinder open to drive out the the others.
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