Sounds like you have most of the protective gear covered.
With that amount to spray I would use the wind to my advantage.
Always spray into the wind. If you are spraying with the wind, stop and let the drift settle before turning back into it.
I know a guy that custom sprayed 1000's of acres a year with an open station tractor. He ran most days no matter the wind direction and all day long for weeks. He sprayed this way for 15 years. He went to a cab with charcoal filters about 30 years ago.
He is now 70 years old and doing fine.