I just finished a round of doxycycline. I had a tick in my leg three weeks ago. My wife removed it, including the the head. The next day I had a hole about 1/4 inch in dia. I have had many ticks but never anything like this. Doc started me on antibiotics. After three weeks I still have a swollen red area.
And the sun will affect your skin when taking Doxycycline. Mine actually felt like it was on fire.