It can make you anxious, there is no doubt, being comfortable with flying or not. I used to fly out west quite often, in the mid 90's, was not afraid of it, nor heights, and realized that when I got to my destination, there are so many places to see and things to do. Had I let any fear of flying get to me, I'd never have been able to ski Purgatory, Telluride, and Wolf Creek in Colorado. Nor would I have seen the Mesa Verde, Monument Valley, Grand Canyon, most of Arizona, southern California etc., + all the stops in between. Having flown to Albuquerque, then driving to the rest of those places, spent more time seeing and doing than driving, kind of makes a few hours in the air worth it, besides the odds are with you.
I had serious reservations after 9-11, because I was a few blocks north of the WTC when it happened and saw things that were difficult to comprehend. Following that terrible event my job required quite a bit of travel and the first time I got on a plane again, it just created a lot of anxiety, anticipation and the like. I can see where a mild sedative, maybe a couple of belts of a favorite liquor or something like a Xanax would have easily helped me get over that particular hump, yet I did none of those things, Xanax would have been a good choice seems to work well on me per doctors instructions in times of high stress. That take off was very stressful, lot of things in my recent memory that were hard to deal with, but once in the air, I relaxed and came to grips with it be it. Vacation or work, I concentrated on those things, plus observing out the window, I love doing that even at night, relaxes me to see all the lights, places and so on. Mindset was I have things to do, places to go, people to see, why worry about the minute chance of a problem in flight, and if there was a situation, none of this matters anyway, so what is the point.
Might take a little pushing yourself, and some help from the wife, jump in there and get it done, the next time won't be as bad.
I have not flown in several years, I'll go through it again I'm sure, its all in yer head is what I like to say LOL !